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Groupe 5 - Chimie des Nanomatériaux

Mornet Stéphane

[ - ] publié le 19 février 2014, mis à jour le

- Personnel CNRS

- Chargé de Recherche

- Publications - Citation metrics / ORCID / ResearchGate

- E-mail / tél. :05-40-00-63-35

- Compétences : Ingénierie des nanoparticules (NPs) : synthèse, modification de surface, encapsulation, biofonctionnalisation, NPs nanostructurées et multifonctionnelles, auto-assemblage de nanoparticules. Applications Biomédicales / Nanomatériaux

Education and scientific position

2015 : Accreditation to supervise research (HDR) from University of Bordeaux, in physical chemistry of condensed matter
2007 : CNRS junior scientist (CR1, section 15) : Institute of Condensed Matter Chemistry of Bordeaux (ICMCB), CNRS, France
2006 – 2007 : Postdoctoral fellow : European Commission, Joint Research Centre, Institute for Health and Consumer Protection (IHCP), Nanotechnology and Molecular Imaging Unit, Ispra (Varese)/Italia, Supervisor : F. ROSSI
2002 – 2006 : Postdoctoral fellow : University of Bordeaux, Molecular Imaging and Nano-Biotechnology – UMR CNRS 5471, European Institute of Chemistry and Biology (IECB). Supervisor : A.R. BRISSON
2001 – 2002 : Temporary Lecturer and Research Assistant, University of Bordeaux, Molecular Imaging and Nano-Biotechnology – UMR CNRS 5471, European Institute of Chemistry and Biology (IECB). Supervisor : A.R. BRISSON
2002 : Doctorate in physical chemistry of condensed matter, University of Bordeaux. Advisors : E. DUGUET and J. PORTIER

Research activities

Keywords : Nanoscale surface engineering, i.v. injectable NPs, NP synthesis, Multifunctional hybrid NPs (magnetic, fluorescent, plasmonic, thermosensitive, ferroelectric), Related fields : Bioimaging (MRI, NIR fluorescence imaging), Nanomedicine (drug release, magnetic hyperthermia), Multifunctional nanomaterials for Optics, Multiferroics, Magnetism.

Nanoscale divided matter has a considerable developed surface. Problems related to the control of interactions at the interface become unavoidable when nanoparticles are used in complex environments such as biological media. Mastering nanoscale surface modification is also required in material science for which the surface chemistry impacts an assortment of physical properties.

My research, at the interface of chemistry and biology, focuses on the synthesis of hybrid mono/multifunctional NPs. My objectives are to define nanoscale surface modification strategies in the aim to address critical issues in fields related to nanotechnologies such as nanomedicine, bioimaging, plasmonic, metamaterials and smart materials, among others.

I currently develop three research topics :

1- Design of nanoparticles for biomedical applications :
Development of optimized PEGylation routes for intravenously administered long circulating NPs ; conjugation with biomolecules (antibodies and fragments, proteins, peptides, aptamers, nucleic acids, lipids) for bioimaging (MRI, NIR fluorescence imaging) ; development of nanocarriers (silica-based mesoporous NPs) for heat-triggered drug release induced under a magnetic field (magnetic) or near infra-red irradiation (plasmonic) ; Biofunctionalized magnetic nanoparticles for extracellular vesicles extraction and purification.
2- Surface chemistry for nanomaterial development :
Design of surface chemistry and coating strategies (SiO2, MgO, TiO2, Au,…) for the synthesis of multifunctional nanobuilding blocks used in extrinsic multiferroic ceramics ; plasmonic nanoresonators for metamaterials ; or used in the development of assembled nanomaterials (magnetic, plasmonic and/or ferroelectric).
3- Nanoparticles for Nano(eco)toxicology :
Tailor-made nanoparticles (Au, Ag, SiO2, TiO2) of controlled size, shape, physical surface properties (surface charge, HLB, hydrodynamic diameter) for toxicological studies ; NP labelling for tracking from cellular level (internalization) to tissues (translocation) and to the whole animal model (biodistribution) ; Colloidal stabilization in complex media (natural aquatic systems, physiological media…).

National Collaborations
Dr. Franck Couillaud (IMOTION, Bordeaux)
Prof. Alain Brisson, Dr. Olivier Lambert (CBMN, Bordeaux)
Dr. Gisèle Clofent-Sanchez (RMSB, Bordeaux)
Prof. Sylvie Crauste-Manciet, Dr. Philippe Barthelemy, Laurent Azema (ARNA, Bordeaux)
Dr Olivier Sandre, Christophe Schatz, Guillaume Fleury, Dr Karim Aïssou, Prof. Georges Hadziioannou, (LCPO, Bordeaux)
Prof. Magalie Baudrimont, Prof. Agnès Feurtet-Mazel (EPOC, Bordeaux)
Dr. Jean-François Berret (Matière et Systèmes complexes, Paris-Diderot)
Dr. Mireille Blanchard-Desde, Yannick Crémilleux (ISM, Bordeaux)
Prof. Armelle Baeza-Squiban (RMCX, Paris-Diderot)
Prof. Serge Ravaine, Dr Philippe Barois, Renaud Vallee (CRPP, Bordeaux)
Prof. Olivier Tillement, Dr. Jean-François Lux (ILM, Lyon)
Prof. Mona Treguer, Prof. Graziella Goglio, Prof Etienne Duguet, Dr. Guillaume Chastanet, Dr. Manuel Gaudon, Dr. Cathy Ellisalde, Dr. Mario Maglione, Dr. Glenna Drisko, Dr. Jerôme Majimel (ICMCB, Bordeaux)

International Collaborations
Prof. Fernando Plazaola, Jose Angel Garcia, Eneko Garaio (UPV/EHU, Leioa, Bilbao, Spain)
Dr. Christoph Hagemeyer (Monash University, Australia)
Dr Ondrej Kaman (ACSR, Prague, Czech Republic)
Dr Christophe Detrembleur and Prof. Christine Jérôme (CERM, Liège, Belgium)

Industrial collaborations
Toyal Europe, Fabrice Morvan
NHtheraguix, Dr. Tristan Doussineau, ongoing project

Ongoing research projects
Involved in 6 TRAIL LabEx projects and 1 AMADeus LabEx project
CITTOXIC, ANR project, WP Leader Project (2014-2018)
HEROES, ANR project (Led by Dr. Guillaume Chastanet, 2017-21), partner
La Ligue contre le cancer (2016-17)

Scientific production and supervision

105 peer-reviewed articles / 20 proceedings / 4 book chapters/ 3 patents

27 invited talks, 21 international conferences (7 invited)

Supervision : 8 PhD students (currently 4), 8 postdoctoral fellows, 25 master students (currently 1), 8 undergraduate students (currently 1)

10 Relevant publications (in the last 4 years)

  1. Impact of surface grafting density of PEG macromolecules on dually fluorescent silica nanoparticles used for the in vivo imaging of subcutaneous tumors. L. Adumeau, C. Genevois, L. Roudier, C. Schatz, F. Couillaud*, S. Mornet*, BBA Gen. Subj., 1861, 1587-1596 (2017)
  2. In vivo imaging of local gene expression induced by magnetic hyperthermia. O. Sandre*, C. Genevois, E. Garaio, L. Adumeau, S. Mornet, F. Couillaud*, Genes, 8(61), 1-13 (2017)
  3. Graft of gold on spin-crossover nanoparticles : SCO@Au. L. Moulet, N. Daro, S. Mornet*, N. Vilar-Vidal, G. Chastanet and P. Guionneau*, Chem. Commun. 52, 13213-13216 (2016)
  4. Visible-transparent and UV/IR-opaque colloidal dispersions of Ga-doped zinc oxide nanoparticles. I. Trenque, M. Gaudon, E. Duguet, S. Mornet*, New J. of Chem., 40 (8),7204-7209 (2016)
  5. Solid Lipid Nanoparticles for image-guided therapy of Atherosclerosis. K. Oumzil, M. A. Ramin, C. Lorenzato, A. Hémadou, J. Laroche, M.-J. Jacobin-Valat, S. Mornet, C.-E. Roy, T. Kauss, K. Gaudin, G. Clofent-Sanchez and P. Barthélémy, Bioconj. Chem. 27(3), 569-575 (2016)
  6. Quaternary Ammonium Groups Exposed at the Surface of Silica Nanoparticles Suitable for DNA Complexation in the Presence of Cationic Lipids. N. Reinhardt, L. Adumeau, O. Lambert, S. Ravaine and S. Mornet*, J. Phys Chem B, 119, 6401-6411 (2015)
  7. Optimization of magnetic inks made of L10-ordered FePt nanoparticles and polystyrene-block-poly(ethylene oxide) copolymers. B. Basly, T. Alnasser, K. Aissou, G. Fleury, G. Hadziioannou, E. Duguet, G. Goglio and S. Mornet*, Langmuir 31 (24), 6675–6680 (2015)
  8. Extracellular Vesicles from Blood Plasma : Determination of their morphology, size, phenotype and concentration. N. Arraud, R. Linares, S. Tan, C. Gounou, J.-M. Pasquet, S. Mornet, A. R. Brisson, J. Thromb. Homeost. 12(5), 614–627, (2014)
  9. From Core-Shell BaTiO3@MgO to Nanostructured Low Dielectric Loss Ceramics by Spark Plasma Sintering. R. Berthelot, B. Basly, J. Majimel, G. Chevallier, A. Weibel, A. Veillère, U-C. Chung, G. Goglio, M. Maglione, C. Estournès, S. Mornet*, C. Ellisalde*, J Mater Chem C, 2(4), 683-690 (2014)
  10. Heat-triggered Drug Release Systems based on Mesoporous Silica Nanoparticles Filled with a Maghemite Core and Phase-change Molecules as Gatekeepers. J. Liu, C. Detrembleur, A. Debuigne, M.-C. De Pauw-Gillet, S. Mornet, L. Vander Elst, S. Laurent, C. Jerome, E. Duguet, J. Mater. Chem. B, 2, 59–70 (2014)

Book chapters and edition)

Hybrid magnetic nanoparticles for targeted delivery. R. Epherre, G. Goglio, S. Mornet and E. Duguet, Comprehensive Biomaterials, vol. 4, pp. 575-593 Elsevier, Edited by P. Ducheyne, K.E. Healy, D.W. Hutmacher, D.W. Grainger, C.J. Kirkpatrick, Amsterdam : Elsevier, 2011. p. 575-593. ISBN 978-0-08-055302-3

Synthesis and characterization of iron oxide ferrite nps and ferrite-based aqueous fluids. E. Duguet, M.-H. Delville, S. Mornet, Magnetic nanoparticles : From fabrication to clinical applications : theory to therapy, chemistry to clinic, bench to bedside, Edited by Nguyen Thi Kim Thanh, Boca Raton (Fla.) : CRC Press, 2012. p. 47-72. ISBN 978-1-4398-6932-1

Magnetic nanoparticles for magnetic resonance imaging and hyperthermia applications. E. Pollert, G. Goglio, S. Mornet and E. Duguet, Springer book, R. Brayner, T. Coradin and F. Fievet Editors, Nanomaterials : A Danger or a Promise ?, Springer-Verlag London, 2012. p. 99-129. ISBN 978-1-4471-4213-3

The main challenges on surface biofunctionalization for MNP in vivo targeting. L. Adumeau ; M. H. Delville ; S. Mornet*. Clinical applications of magnetic nanoparticles, edited by Nguyen Thi Kim Thanh, to be published in 2018 by CRC Press/Taylor and Francis. ISBN 978-1-138-05155-3

Guest Editor for a special issue “Nanoscale Surface Engineering “ in Nanomaterials, MPDI. Coming soon